In humans, there are two skeletal muscle α‐actinins, encoded by ACTN2 and ACTN3, and the ACTN3 genotype is associated with human athletic performance. Remarkably, approximately 1 billion people worldwide are deficient in α‐actinin‐3 due to the common ACTN3 R577X polymorphism. The α‐actinins are an ancient family of actin‐binding proteins with structural, signalling and metabolic functions. The skeletal muscle α‐actinins diverged ∼250–300 million years ago, and ACTN3 has since developed restricted expression in fast muscle fibres. Despite ACTN2 and ACTN3 retaining considerable (...) sequence similarity, it is likely that following duplication there was a divergence in function explaining why α‐actinin‐2 cannot completely compensate for the absence of α‐actinin‐3. This paper focuses on the role of skeletal muscle α‐actinins, and how possible changes in functions between these duplicates fit in the context of gene duplication paradigms. (shrink)

Despite promising early work into the role of immune cells such as eosinophils in adipose tissue (AT) homeostasis, recent findings revealed that elevating the number of eosinophils in AT alone is insufficient for improving metabolic impairments in obese mice. Eosinophils are primarily recognized for their role in allergic immunity and defence against parasitic worms. They have also been detected in AT and appear to contribute to adipose homeostasis and drive energy expenditure, but the underlying mechanisms remain elusive. It has long (...) been recognized that immune cells such as macrophages respond to external signals to regulate adipose homeostasis and energy balance, however, less is known about the relevance of eosinophil activity in AT. As the authors propose in this review, given recent debate over the relative importance of their tissue‐specific abundance, the stage is now set for exploring the functionality and activation states of AT eosinophils. (shrink)

Transcriptional silencing may not necessarily depend on the continuous residence of a sequence‐specific repressor at a control element and may act via a “hit and run” mechanism. Due to limitations in assays that detect transcription factor (TF) binding, such as chromatin immunoprecipitation followed by high‐throughput sequencing (ChIP‐seq), this phenomenon may be challenging to detect and therefore its prevalence may be underappreciated. To explore this possibility, erythroid gene promoters that are regulated directly by GATA1 in an inducible system are analyzed. It (...) is found that many regulated genes are bound immediately after induction of GATA1 but the residency of GATA1 decreases over time, particularly at repressed genes. Furthermore, it is shown that the repressive mark H3K27me3 is seldom associated with bound repressors, whereas, in contrast, the active (H3K4me3) histone mark is overwhelmingly associated with TF binding. It is hypothesized that during cellular differentiation and development, certain genes are silenced by repressive TFs that subsequently vacate the region. Catching such repressor TFs in the act of silencing via assays such as ChIP‐seq is thus a temporally challenging prospect. The use of inducible systems, epitope tags, and alternative techniques may provide opportunities for detecting elusive “hit and run” transcriptional silencing. Also see the video abstract here https://youtu.be/vgrsoP_HF3g. (shrink)

Kant makes and elaborates upon a distinction between active citizenship and passive citizenship. Active citizens enjoy the right to vote and rights of political participation generally. Passive citizens do not, though they still enjoy the protection of the law as citizens. Kant’s examples have left commentators puzzling over how these distinctions follow from his stated rationale or justification for active citizenship, namely, that active citizens possess a kind of political and economic self-sufficiency. This essay focuses on one subset passive citizenry (...) – that of traveling blacksmiths, barbers, and day laborers in order to examine Kant’s distinctions. I argue that these examples show that Kant’s concerns regarding dependence are, at least in some cases, pragmatic rather than political. (shrink)

There is an apparent tension between Immanuel Kant's model of moral agency and his often-neglected philosophy of moral education. On the one hand, Kant's account of moral knowledge and decision-making seems to be one that can be self-taught. Kant's famous categorical imperative and related 'fact of reason' argument suggest that we learn the content and application of the moral law on our own. On the other hand, Kant has a sophisticated and detailed account of moral education that goes well beyond (...) the kind of education a person would receive in the course of ordinary childhood experience. The task of this paper will be to reconcile these seemingly conflicting claims. Ultimately, I argue, Kant's philosophy of education makes sense as a part of his moral theory if we look not only at individual moral decisions, but also at the goals or ends that these moral decisions are intended to achieve. In Kant's case, this end is what he calls the highest good, and, I argue, the most coherent account of the highest good is a kind of ethical community and end of history, similar to the Groundwork 's realm of ends. Seen as a tool to bring about and sustain such a community, Kant's philosophy of moral education exists as a coherent and important part of his moral philosophy. (shrink)

Two families of mathematical methods lie at the heart of investigating the hierarchical structure of genetic variation in Homo sapiens: /diversity partitioning/, which assesses genetic variation within and among pre-determined groups, and /clustering analysis/, which simultaneously produces clusters and assigns individuals to these “unsupervised” cluster classifications. While mathematically consistent, these two methodologies are understood by many to ground diametrically opposed claims about the reality of human races. Moreover, modeling results are sensitive to assumptions such as preexisting theoretical commitments to certain (...) linguistic, anthropological, and geographic human groups. Thus, models can be perniciously reified. That is, they can be conflated and confused with the world. This fact belies standard realist and antirealist interpretations of “race,” and supports a pluralist conventionalist interpretation. (shrink)

Scientific inquiry has led to immense explanatory and technological successes, partly as a result of the pervasiveness of scientific theories. Relativity theory, evolutionary theory, and plate tectonics were, and continue to be, wildly successful families of theories within physics, biology, and geology. Other powerful theory clusters inhabit comparatively recent disciplines such as cognitive science, climate science, molecular biology, microeconomics, and Geographic Information Science (GIS). Effective scientific theories magnify understanding, help supply legitimate explanations, and assist in formulating predictions. Moving from their (...) knowledge-producing representational functions to their interventional roles (Hacking 1983), theories are integral to building technologies used within consumer, industrial, and scientific milieus. -/- This entry explores the structure of scientific theories from the perspective of the Syntactic, Semantic, and Pragmatic Views. Each of these views answers questions such as the following in unique ways. What is the best characterization of the composition and function of scientific theory? How is theory linked with world? Which philosophical tools can and should be employed in describing and reconstructing scientific theory? Is an understanding of practice and application necessary for a comprehension of the core structure of a scientific theory? How are these three views ultimately related? (shrink)

I analyze the importance of parts in the style of biological theorizing that I call compositional biology. I do this by investigating various aspects, including partitioning frames and explanatory accounts, of the theoretical perspectives that fall under and are guided by compositional biology. I ground this general examination in a comparative analysis of three different disciplines with their associated compositional theoretical perspectives: comparative morphology, functional morphology, and developmental biology. I glean data for this analysis from canonical textbooks and defend the (...) use of such texts for the philosophy of science. I end with a discussion of the importance of recognizing formal and compositional biology as two genuinely different ways of doing biology – the differences arising more from their distinct methodologies than from scientific discipline included or natural domain studied. Ultimately, developing a translation manual between the two styles would be desirable as they currently are, at times, in conflict. (shrink)

Little extended attention has been given to Kant's notion of self-conceit, though it appears throughout his theoretical and practical philosophy. Authors who discuss self-conceit often describe it as a kind of imperiousness or arrogance in which the conceited agent seeks to impose selfish principles upon others, or sees others as worthless. I argue that these features of self-conceit are symptoms of a deeper and more thoroughgoing failure. Self-conceit is best described as the tendency to insist upon one to oneself or (...) to others s will or inclinations upon others, and more centrally the tendency to reconstruct evidence and rationalize so that one may be convinced of one’s own virtue. While the conceited agent may ultimately impose her judgement upon others, she does so in order to preserve her delusion of virtue. (shrink)

Scientists use models to understand the natural world, and it is important not to conflate model and nature. As an illustration, we distinguish three different kinds of populations in studies of ecology and evolution: theoretical, laboratory, and natural populations, exemplified by the work of R.A. Fisher, Thomas Park, and David Lack, respectively. Biologists are rightly concerned with all three types of populations. We examine the interplay between these different kinds of populations, and their pertinent models, in three examples: the notion (...) of “effective” population size, the work of Thomas Park on /Tribolium/ populations, and model-based clustering algorithms such as /Structure/. Finally, we discuss ways to move safely between three distinct population types while avoiding confusing models and reality. (shrink)

Reification is to abstraction as disease is to health. Whereas abstraction is singling out, symbolizing, and systematizing, reification is neglecting abstractive context, especially functional, historical, and analytical-level context. William James and John Dewey provide similar and nuanced arguments regarding the perils and promises of abstraction. They share an abstraction-reification account. The stages of abstraction and the concepts of “vicious abstractionism,” “/the/ psychologist’s fallacy,” and “the philosophic fallacy” in the works of these pragmatists are here analyzed in detail. For instance, in (...) 1896 Dewey exposes various fallacies associated with reifying dualistic reflex arc theory. The conclusion prescribes treatments (pluralism and assumption archaeology) for de-reifying ill models (i.e., universalized, narrowed, and ontologized models) in contemporary scientific fields such as cognitive science and biology. (shrink)

Analytical categories of scientific cultures have typically been used both exclusively and universally. For instance, when styles of scientific research are employed in attempts to understand and narrate science, styles alone are usually employed. This article is a thought experiment in interweaving categories. What would happen if rather than employ a single category, we instead investigated several categories simultaneously? What would we learn about the practices and theories, the agents and materials, and the political-technological impact of science if we analyzed (...) and applied styles, paradigms, and models simultaneously? I address these questions in general and for a specific case study: a brief history of systematics. (shrink)

Schaffner’s model of theory reduction has played an important role in philosophy of science and philosophy of biology. Here, the model is found to be problematic because of an internal tension. Indeed, standard antireductionist external criticisms concerning reduction functions and laws in biology do not provide a full picture of the limits of Schaffner’s model. However, despite the internal tension, his model usefully highlights the importance of regulative ideals associated with the search for derivational, and embedding, deductive relations among mathematical (...) structures in theoretical biology. A reconstructed Schaffnerian model could therefore shed light on mathematical theory development in the biological sciences and on the epistemology of mathematical practices more generally. *Received November 2006; revised March 2009. †To contact the author, please write to: Philosophy Department, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064; e‐mail: [email protected]. (shrink)

A number of EU institutions and government committees across Europe have expressed interest in developing methods and decision-support tools to facilitate consideration of the ethical dimensions of biotechnology assessment. As part of the work conducted in the EC supported project on ethical tools (Ethical Bio-TA Tools), a number of ethical frameworks with the potential to support the work of public policy decision-makers has been characterized and evaluated. One of these potential tools is the Delphi method. The Delphi method was originally (...) developed to assess variables that are intangible and/or shrouded in uncertainty by drawing on the knowledge and abilities of a diverse group of experts through a form of anonymous and iterative consultation. The method has hitherto been used by a diversity of practitioners to explore issues such as technology assessment, environmental planning, and public health measures. From the original (classical) Delphi, a family of Delphi-related processes has emerged. As a result of the evaluation of the various Delphi processes, it is proposed that the classical method can be further developed and applied as a form of ethical framework to assist policy-makers. Through a series of exercises and trials, an Ethical Delphi has been developed as a potential approach for characterizing ethical issues raised by the use of novel biotechnologies. Advantages and disadvantages of the method are discussed. Further work is needed to develop the procedural aspects of the Ethical Delphi method and to test its use in different cultural contexts. However, utilizing an ethical framework of this type combines the advantages of a methodical approach to capture ethical aspects with the democratic virtues of transparency and openness to criticism. Ethical frameworks such as the Ethical Delphi should contribute to better understanding of and decision-making on issues that involve decisive ethical dimensions. (shrink)

Gillian Russell has recently proposed counterexamples to such elementary argument forms as Conjunction Introduction and Identity. These purported counterexamples involve expressions that are sensitive to linguistic context—for example, a sentence which is true when it appears alone but false when embedded in a larger sentence. If they are genuine counterexamples, it looks as though logical nihilism—the view that there are no valid argument forms—might be true. In this paper, I argue that the purported counterexamples are not genuine, on the grounds (...) that they equivocate. Having defused the threat of logical nihilism, I argue that the kind of linguistic context sensitivity at work in Russell’s purported counterexamples, if taken seriously, far from leading to logical nihilism, reveals new, previously undreamt-of valid forms. By way of proof of concept I present a simple logic, Solo-Only Propositional Logic, designed to capture some of them. Along the way, some interesting subtleties about the fallacy of equivocation are revealed. (shrink)

Levins and Lewontin have contributed significantly to our philosophical understanding of the structures, processes, and purposes of biological mathematical theorizing and modeling. Here I explore their separate and joint pleas to avoid making abstract and ideal scientific models ontologically independent by confusing or conflating our scientific models and the world. I differentiate two views of theorizing and modeling, orthodox and dialectical, in order to examine Levins and Lewontin’s, among others, advocacy of the latter view. I compare the positions of these (...) two views with respect to four points regarding ontological assumptions: (1) the origin of ontological assumptions, (2) the relation of such assumptions to the formal models of the same theory, (3) their use in integrating and negotiating different formal models of distinct theories, and (4) their employment in explanatory activity. Dialectical is here used in both its Hegelian–Marxist sense of opposition and tension between alternative positions and in its Platonic sense of dialogue between advocates of distinct theories. I investigate three case studies, from Levins and Lewontin as well as from a recent paper of mine, that show the relevance and power of the dialectical understanding of theorizing and modeling. (shrink)

In his published texts and lectures on moral philosophy, Kant repeatedly singles out gratitude for discussion. Nevertheless, puzzles about the derivation, content, and nature of this duty remain. This paper seeks to solve some of these puzzles. Centrally, I argue that it is essential to attend to a distinction that Kant makes between well-wishing benevolence (Wohlwollen) and active beneficence (Wohlthun) on the part of a benefactor. On the Kantian account, I argue, a different type of gratitude is owed in response (...) to each. With this distinction in place, I argue further that we can construct what many have thought to be missing from Kant’s discussion of gratitude – an argument explicating the precise contradiction generated by a maxim of ingratitude. (shrink)

The notion of rigidity looms large in philosophy of language, but is beset by difficulties. This paper proposes a simple theory of rigidity, according to which an expression has a world-relative semantic property rigidly when it has that property at, or with respect to, all worlds. Just as names, and certain descriptions like The square root of 4, rigidly designate their referents, so too are necessary truths rigidly true, and so too does cat rigidly have only animals in its extension. (...) After spelling out the theory, I argue that it enables us to avoid the headaches that attend the misbegotten desire to have a simple rigid/non-rigid distinction that applies to expressions, giving us a simple solution to the problem of generalizing the notion of rigidity beyond singular terms. (shrink)

Geographic Information Science (GIS) is an interdisciplinary science aiming to detect and visually represent patterns in spatial data. GIS is used by businesses to determine where to open new stores and by conservation biologists to identify field study locations with relatively little anthropogenic influence. Products of GIS include topographic and thematic maps of the Earth’s surface, climate maps, and spatially referenced demographic graphs and charts. In addition to its social, political, and economic importance, GIS is of intrinsic philosophical interest due (...) to its methodological richness and because it is an instructive analogue to other sciences. This chapter works towards a philosophy of GIS and cartography, or PGISC. In particular, it examines practices of classifying geographic space, objects, and relations. By focusing on the use of natural kinds in data modeling and map generalization practices, I show how the making and using of kinds is contextual, fallible, plural, and purposive. (shrink)

Selectionist evolutionary theory has often been faulted for not making novel predictions that are surprising, risky, and correct. I argue that it in fact exhibits the theoretical virtue of predictive capacity in addition to two other virtues: explanatory unification and model fitting. Two case studies show the predictive capacity of selectionist evolutionary theory: parallel evolutionary change in E. coli, and the origin of eukaryotic cells through endosymbiosis.

According to a standard story, part of what we have in mind when we say that an argument is valid is that it is necessarily truth preserving: if the premises are true, the conclusion must also be true. But—the story continues—that’s not enough, since ‘Roses are red, therefore roses are coloured’ for example, while it may be necessarily truth-preserving, is not so in virtue of form. Thus we arrive at a standard contemporary characterisation of validity: an argument is valid when (...) it is NTP in virtue of form. Here I argue that we can and should drop the N; the resulting account is simpler, less problematic, and performs just as well with examples. (shrink)

This paper considers the role of ‘vices of culture’ in Immanuel Kant’s account of radical evil and education. I argue that Kant was keenly aware of a uniquely human tendency to allow a self-centered concern for status to misunderstand or co-opt the language of dignity and equal worth for its own purposes. This tendency lies at the root of the ‘vices of culture’ and ‘aggravated vices’ that Kant describes in the Religion and Doctrine of Virtue, respectively. When it comes to (...) moral education, then, it will be crucial that the developing agent have a clear understanding of the shared dignity of rational agents and the particular duties that are defined, in part, by their tendency to alter status among agents. I argue that the casuistical questions that Kant attaches to these discussions in the Doctrine of Virtue are an example of a pedagogical device that might help pupils to overcome this tendency so closely associated with radical evil. (shrink)

I defend Haze’s argument against the Breckenridge-Magidor theory of instantial reasoning from an objection by Meléndez Gutiérrez. According to Breckenridge and Magidor, in reasoning like ‘Some x is mortal. Let n be such an x…’, the ‘n’ refers to a particular object but we cannot know which. This surprisingly defensible view poses an obvious threat to widespread notions in the philosophy of language. Haze argues that the theory leads to absurdity in cases like ‘Some x is unreferred-to by any expression. (...) Let n be such an x…’ and should therefore be rejected. Meléndez Gutiérrez counters that Haze’s argument is just a case of Berry-like paradox and thus fails to refute the Breckenridge-Magidor theory. I argue that the analogy breaks down: unlike the intuitively compelling and widely believed well-ordering principle about positive integers, the principle drawn from Breckenridge and Magidor that plays a supposedly analogous role enjoys no such status, and is instead simply shown to be false by Haze’s reductio. The possibility of such a response is obscured when Meléndez Gutiérrez portrays Haze’s argument as involving a stipulation that ‘n’ is to refer to an unreferred-to object. On the contrary, Haze’s argument does not assume that expressions like ‘n’ work by means of referring at all, and simply lets stipulations like ‘Let n be such an x’ be themselves, without imposing a theory on them. Once this is clarified, we can see that Haze’s argument is unaffected by Meléndez Gutiérrez’s objection. (shrink)

This paper introduces two languages and associated logics designed to afford perspicuous representations of a range of natural language arguments involving adverbs and the like: first-order logic with basic adverbs (FOL-BA) and first-order logic with scoped adverbs (FOL-SA). The guiding logical idea is that an adverb can come between a term and the rest of the statement it is a part of, resulting in a logically stronger statement. I explain various interesting challenges that arise in the attempt to implement the (...) guiding idea, and provide solutions for some but not all of them. I conclude by outlining some directions for further research. (shrink)

Typically, Kant describes maxims that violate the moral law as engaging in a kind of comparative judgement: the person who makes a false promise judges it best – at least subjectively – to deceive her friend. I argue that this is not the only possible account of moral failure for Kant. In particular, when we examine maxims of so-called despondency (Verzagtheit) we find that some maxims are resistant to comparative judgement. I argue that this is true for at least two (...) reasons: first, the despondent agent has a maxim to avoid suffering at all costs; second, this anxious preoccupation with suffering makes the despondent agent prone to failures associated with the imagination and its role in creating an ideal of happiness. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

The recent work by Buchbinder et al. (2024) that draws on the experiences of clinicians during the COVID-19 pandemic to examine concepts of moral stress, injury and distress, provides a useful fram...

Concerned to make certain a difference between the human and its machinic simulation, two films released at the start of the new millennium put the trope of the Oedipal at the heart of their action. In doing so, both succeed in establishing the real of the human within its terms. However, by taking the Oedipal as the figure of this difference, both films also unleash a set of possibilities for being human in the new millennium that may not have been (...) entirely expected. In a close reading of both Artificial Intelligence (Steven Spielberg, 2001) and I, Robot (Alex Proyas, 2004), this article examines the possibilities for human being as they come to circulate within the narrative structures of both films. In doing so it also examines the further difference drawn between what each film offers as the literal and metaphorical rendition of the Oedipal itself. With the metaphorical opened to the space and time of being excluded as a possibility in its literal rendition, the consequences of the subsequent process of becoming of the human are finally laid bare. (shrink)

Philosophical counseling offers a depathologizing practice that can benefit both the practitioner and the client. Philosopher Michel Foucault’s account of biopower is a useful analytic of the psychopathologization of everyday life, and can show the social signif­icance of philosophical practice. This essay critiques the conflation, by some philosophical practitioners, of the medical disease model and all psychotherapeutic methods. Foucault’s conflation of human normativity and normalization is also critiqued. Historian of science Georges Canguilhem’s alternative account of human normativity within the medical (...) disease model is offered as an antidote to the conflations by these philosophical practitioners and Foucault. Philosophical practitioners ought to give up objectivist claims to value neutrality and acknowledge that the interventions of philosophical counseling in clinical diagnostic discourses are normative, theory-laden, and politically significant. (shrink)

As humans interact in the world, they often orient one another's attention to objects through the use of spoken demonstrative expressions and head and/or hand movements to point to the objects. Although indicating behaviors have frequently been studied in lab settings, we know surprisingly little about how demonstratives and pointing are used to coordinate attention in large-scale space and in natural contexts. This study investigates how speakers of Quiahije Chatino, an indigenous language of Mexico, use demonstratives and pointing to give (...) directions to named places in large-scale space across multiple scales. The results show that the use and coordination of demonstratives and pointing change as the scale of search space for the target grows. At larger scales, demonstratives and pointing are more likely to occur together, and the two signals appear to manage different aspects of the search for the target: demonstratives orient attention primarily to the gesturing body, while pointing provides cues for narrowing the search space. These findings underscore the distinct contributions of speech and gesture to the linguistic composite, while illustrating the dynamic nature of their interplay.s in Spanish and Quiahije Chatino are provided as appendices.Se incluyen como apéndices resúmenes en español y en el chatino de San Juan Quiahije. SonGktyiCreCinH, ngyaqCskaEktyiCnoEndaHsonBnaFngaJnoIngyaqCloEktyiCreC, ngyaqCranFchaqExlyaKqoEchaqFjnyaJnoAndywiqArenqAKchinAKyqyaC. (shrink)

Work on the nature and scope of formal logic has focused unduly on the distinction between logical and extra-logical vocabulary; which argument forms a logical theory countenances depends not only on its stock of logical terms, but also on its range of grammatical categories and modes of composition. Furthermore, there is a sense in which logical terms are unnecessary. Alexandra Zinke has recently pointed out that propositional logic can be done without logical terms. By defining a logical-term-free language with the (...) full expressive power of first-order logic with identity, I show that this is true of logic more generally. Furthermore, having, in a logical theory, non-trivial valid forms that do not involve logical terms is not merely a technical possibility. As the case of adverbs shows, issues about the range of argument forms logic should countenance can quite naturally arise in such a way that they do not turn on whether we countenance certain terms as logical. (shrink)

There is a line of thought, neglected in recent philosophy, according to which a priori knowable truths such as those of logic and mathematics have their special epistemic status in virtue of a certain tight connection between their meaning and their truth. Historical associations notwithstanding, this view does not mandate any kind of problematic deflationism about meaning, modality or essence. On the contrary, we should be upfront about it being a highly debatable metaphysical idea, while nonetheless insisting that it be (...) given due consideration. From this standpoint, I suggest that the Finean distinction between essence and modality allows us to refine the view. While liberal about meaning, modality and essence, the view is not without bite: it is reasonable to suppose that it is able to ward off philosophical confusions stemming from the undue assimilation of a priori to empirical knowledge. (shrink)

There are two fundamentally distinct kinds of biological theorizing. "Formal biology" focuses on the relations, captured in formal laws, among mathematically abstracted properties of abstract objects. Population genetics and theoretical mathematical ecology, which are cases of formal biology, thus share methods and goals with theoretical physics. "Compositional biology," on the other hand, is concerned with articulating the concrete structure, mechanisms, and function, through developmental and evolutionary time, of material parts and wholes. Molecular genetics, biochemistry, developmental biology, and physiology, which are (...) examples of compositional biology, are in serious need of philosophical attention. For example, the very concept of a "part" is understudied in both philosophy of biology and philosophy of science. ;My dissertation is an attempt to clarify the distinction between formal biology and compositional biology and, in so doing, provide a clear philosophical analysis, with case studies, of compositional biology. Given the social, economic, and medical importance of compositional biology, understanding it is urgent. For my investigation, I draw on the philosophical fields of metaphysics and epistemology, as well as philosophy of biology and philosophy of science. I suggest new ways of thinking about some classic philosophy of science issues, such as modeling, laws of nature, abstraction, explanation, and confirmation. I hint at the relevance of my study of two kinds of biological theorizing to debates concerning the disunity of science. (shrink)

Developing a suggestion of Wittgenstein, I provide an account of truth tables as formulas of a formal language. I define the syntax and semantics of TPL (the language of Tabular Propositional Logic), and develop its proof theory. Single formulas of TPL, and finite groups of formulas with the same top row and TF matrix (depiction of possible valuations), are able to serve as their own proofs with respect to metalogical properties of interest. The situation is different, however, for groups of (...) formulas whose top rows differ. For them I provide (i) a tree-style system of ‘row tree proofs’, which is shown to be sound and complete, and (ii) an alternative, re-writing strategy. (shrink)

This year’s topic is “Genomics and Philosophy of Race.” Different researchers might work on distinct subsets of the six thematic clusters below, which are neither mutually exclusive nor collectively exhaustive: (1) Concepts of ‘Race’; (2) Mathematical Modeling of Human History and Population Structure; (3) Data and Technologies of Human Genomics; (4) Biological Reality of Race; (5) Racialized Selves in a Global Context; (6) Pragmatic Consequences of ‘Race Talk’ among Biologists.

This conversational opinion article between two parties – Kate, a disability performance scholar and Sarah, an interdisciplinary artist-scholar with lived experience of disability – considers the dancing body as redeemer in the specific case of a dancer experiencing ‘chemo fog’, or Chemotherapy-Related Cognitive Impairment (CRCI) after undergoing oncological treatments for Hodgkin Lymphoma. This work draws on Pini’s own lived experience of illness (Pini & Pini, 2019) in dialogue with Maguire-Rosier’s study of dancers with hidden impairments (Gibson & Maguire-Rosier, 2020). (...) In an exploratory account based on an interview with one another, the authors ask: when our senses and perceptions of ourselves and the world we become are obfuscated, what is the nature of the new relationship between the performing self and its absent body/mind/world? How can we shape our narrative and articulate who we are, what we are doing or where we are going, if we are moving in the ‘fog’? Our discussion reveals how Pini’s dancing body elucidates healing, while recovering an agentic perspective in her experience of alienation and frustration tied to chemo fog and related impairments. With this work we offer an original perspective on how a dancing body can resist theoretical diagnosis. (shrink)

This commentary analyzes the extent to which the incommensurability problem can be resolved through the proposed alternative method of integrative experiment design. We suggest that, although one aspect of incommensurability is successfully addressed (dimensional incommensurability), the proposed design space method does not yet alleviate another major source of discontinuity, which we call conceptual incommensurability.

This article explores the idea that there is a spectrum of individuals who feel compelled to dwell in the past, either due to psychological or social conditions. I analyze both conditions respectively by critically examining two cases: post-traumatic stress disorder and racialized oppression. I propose that individuals with PTSD can feel psychologically compelled to dwell in the past in a dually negative sense: the individual lives in the past but also broods on it, causing them to feel “stuck” in the (...) past. This kind of “dwelling” can cause individuals to suffer disruptions to their sense of self and intersubjectivity. After exploring the psychological case of dwelling in the past, I explore the social sense in which individuals can dwell in the past due to oppressive social structures by examining the case of racialized oppression. The case of racialization is philosophically stimulating because of its intersubjective dimensions—it subverts the idea that dwelling in the past is simply a psychological phenomenon by capturing that others can help or hinder us with maintaining a sense of self and future-directed intentionality. By putting the phenomenological work of Al-Saji into conversation with recent phenomenological research on incarceration, I propose that racialization can be similarly disruptive to one’s sense of self and intersubjectivity. The proposed account is suggestive that traumatic and oppressive experiences may amplify and compound each other in ways not yet well elucidated in the literature. If this account is taken to be persuasive, it is indicative that both psychological and social conditions mediate one’s temporality and well-being. (shrink)